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Article

The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2005

Ren Jinyu, Shi Mingan, Liu Renshui, Yang Qi-Heng, Johnson Teri, Skarnes William C, Du Chunying

Abstract excerpt

Baculoviral inhibitor of apoptosis repeat-containing (Birc)6 gene/BIRC6 (Bruce/APOLLON) encodes an inhibitor of apoptosis and a chimeric E2/E3 ubiquitin ligase in mammals. The physiological role of Bruce in antiapoptosis is unknown. Here, we show that deletion of the C-terminal half of Bruce, inc...

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Source

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Identifiers

PMID: 15640352
DOI: 10.1073/pnas.0408744102
PMCID: PMC543482

Genes

TNF
UBC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15640352-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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