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Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma

11 May 2005

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) comprises molecularly distinct subgroups such as activated B-cell-like (ABC) and germinal center B-cell-like (GCB) DLBCLs. We previously reported that CD5(+) and CD5(-)CD10(+) DLBCL constitute clinically relevant subgroups. To determine whether these 2 subgroups are related to ABC and GCB DLBCLs, we analyzed the genomic imbalance of 99 cases (36 CD5(+), 19 CD5(-)CD10(+), and...

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PMID: 15886317
DOI: 10.1182/blood-2005-02-0542

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