Article
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.
Nature immunology - 1 Dec 2002
Gilfillan Susan, Ho Emily L, Cella Marina, Yokoyama Wayne M, Colonna Marco
Abstract excerpt
NKG2D is a receptor on natural killer (NK) cells and cytotoxic T lymphocytes that binds major histocompatibility complex (MHC) class I-like ligands expressed primarily on virally infected and neoplastic cells. In vitro studies indicate that NKG2D provides costimulation through an associated adapter, DAP10, which recruits phosphatidylinositol-3 kinase. Here we show that in DAP10-deficient mice, CD8+ T cells lack...
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