Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder.

Neuroscience letters - 1 Jan 2000

Otani Kyohei, Ujike Hiroshi, Tanaka Yuji, Morita Yukitaka, Katsu Takeshi, Nomura Akira, Uchida Naohiko, Hamamura Takashi, Fujiwara Yutaka, Kuroda Shigetoshi

Abstract excerpt

Several genetic studies have revealed that bipolar disorders are linked with the chromosomal locus of 15q11-q13, where the gamma-aminobutyric acid (GABA) receptor alpha5 subunit gene (GABRA5) locates. GABA is one of the major neurotransmitters that may be involved in the pathogenesis of bipolar disorder. Five polymorphisms in the GABRA5 gene, -754C>T in the promoter region, IVS1-21G>A, IVS2-26T>A, (*)302C>T in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Incidence

Share to Receptors, GABA-A

Share to Risk Assessment

Share to Single-Blind Method

Source

Identifiers

PMID: 15882799
DOI: 10.1016/j.neulet.2005.02.010

Genes

GABRA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder.PMID 15882799Read ↗

Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders.Semantic proximity Read ↗

GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome 15q11-q13 and bipolar disorder: a genetic association study.Semantic proximity Read ↗

Association analysis of chromosome 5 GABAA receptor cluster in Japanese schizophrenia patients.Semantic proximity Read ↗

Association of alpha subunit of GABAA receptor subtype gene polymorphisms with epilepsy susceptibility and drug resistance in north Indian population.Semantic proximity Read ↗

Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia.Semantic proximity Read ↗

Dinucleotide repeat polymorphism at the GABAA receptor alpha 5 (GABRA5) locus at chromosome 15q11-q13.Semantic proximity Read ↗

Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder.Semantic proximity Read ↗

Association between GABA-A receptor alpha 5 subunit gene locus and schizophrenia of a later age of onset.Semantic proximity Read ↗

Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia.Semantic proximity Read ↗

Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.Semantic proximity Read ↗

Association of GABAA Receptor Gene with Epilepsy Syndromes.Semantic proximity Read ↗

No evidence for significant association between GABA receptor genes in chromosome 15q11-q13 and autism in a Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.