Article
A coalescent-based method for detecting and estimating recombination from gene sequences.
Genetics - 1 Mar 2002
McVean Gil, Awadalla Philip, Fearnhead Paul
Abstract excerpt
Determining the amount of recombination in the genealogical history of a sample of genes is important to both evolutionary biology and medical population genetics. However, recurrent mutation can produce patterns of genetic diversity similar to those generated by recombination and can bias estimates of the population recombination rate. Hudson 2001 has suggested an approximate-likelihood method based on...
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