Article
Linkage disequilibrium as a signature of selective sweeps.
Genetics - 1 Jul 2004
Kim Yuseob, Nielsen Rasmus
Abstract excerpt
The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique distribution of allele frequencies and spatial distribution of polymorphic sites. A composite-likelihood test was previously designed to detect these signatures of a selective sweep, solely on the basis of the spatial distribution and marginal allele frequencies of polymorphisms. As an excess of linkage disequilibrium (LD)...
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