The coupon collector and the suppressor mutation: estimating the number of compensatory mutations by maximum likelihood.

Abstract excerpt

Compensatory mutation occurs when a loss of fitness caused by a deleterious mutation is restored by its epistatic interaction with a second mutation at a different site in the genome. How many different compensatory mutations can act on a given deleterious mutation? Although this quantity is fundamentally important to understanding the evolutionary consequence of mutation and the genetic complexity of adaptation,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Epistasis, Genetic
• Share to Evolution, Molecular
• Share to Likelihood Functions