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Reversion is most likely under high mutation supply when compensatory mutations do not fully restore fitness costs.

G3 (Bethesda, Md.) - 25 Aug 2022

Pennings Pleuni S, Ogbunugafor C Brandon, Hershberg Ruth

Abstract excerpt

The dynamics of adaptation, reversion, and compensation have been central topics in microbial evolution, and several studies have attempted to resolve the population genetics underlying how these dynamics occur. However, questions remain regarding how certain features-the evolution of mutators and whether compensatory mutations alleviate costs fully or partially-may influence the evolutionary dynamics of...

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PMID: 35920784
DOI: 10.1093/g3journal/jkac190
PMCID: PMC9434179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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