Article
NFkappaB1 gene does not affect type 1 diabetes predisposition in a Spanish population.
Tissue antigens - 1 Feb 2006
Martínez A, Santiago J L, de la Calle H, Figueredo M A, Fernández-Arquero M, de la Concha E G, Urcelay E
Abstract excerpt
The chromosomal location of the NFkappaB1 gene on 4q, a region linked to type 1 diabetes (T1D), together with the observed resistance to T1D of NFkappaB1-deficient mice, suggests its potential role as candidate gene increasing diabetes predisposition. Previous association studies in diverse populations yielded inconclusive results. Two polymorphisms in the promoter region of the NFkappaB1 gene have been studied:...
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