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The Anaphase Promoting Complex: A Critical Target for Viral Proteins and Anti-Cancer Drugs

28 Jan 2005

Abstract excerpt

The study of animal viruses has provided extraordinary insights into cell cycle dynamics and tumor biology. The significance of the p53 and Rb tumor suppressor proteins, for example, was discovered due to their interactions with viral oncogenes. In the past several years, investigations with four viral proteins, human immunodeficiency virus type 1 (HIV-1) vpr, adenovirus E4orf4, chicken anemia virus (CAV) apoptin...

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PMID: 15876865
DOI: 10.4161/cc.4.4.1606

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