Article

Viral inhibition of the anaphase promoting complex enhances replication by elevating nucleotide pools

2026-01-26

Abstract excerpt

The anaphase promoting complex/cyclosome (APC/C) is a large, ubiquitin ligase and a central regulator of cell cycle progression. By targeting key substrates for degradation during mitosis and G1 phase, the APC/C coordinates metabolic fluctuations that occur during the cell cycle. A diverse range of viruses have convergently evolved mechanisms to bind and inhibit the APC/C; however, a molecular understanding for th...

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Literature Corpus work: 4499a5c9-caf3-5e7c-8cda-adda310e26d9
DOI: 10.64898/2026.01.26.701660

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