Article
Modulation of BCRP mediated atypical multidrug resistance phenotype by RNA interference.
Neoplasma - 1 Jan 2005
Li W T, Zhou G Y, Song X R, Chi W L, Ren R M, Wang X W
Abstract excerpt
Multidrug resistance (MDR) in human cancers is one of the major causes of failure of chemotherapy. The emergence of breast cancer resistance protein (BCRP), a member of the ABC transporter family, has necessitated the development of antagonists. To overcome the BCRP-mediated atypical multidrug drug resistance, two small interfering RNA constructs (RNAi) targeting two different regions of BCRP mRNA were designed...
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