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Article

Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference

1 Dec 2004

Abstract excerpt

Overexpression of the breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance (MDR) to tumor cells and often limits the efficacy of chemotherapy. To circumvent BCRP-mediated MDR, a common approach is the use of potent and specific inhibitors of BCRP transport such as fumitremorgin C, novobiocin, and GF120918. Here, we evaluated a new approach using RNA interference for the specific knockdown of...

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PMID: 15634651
DOI: 10.1158/1535-7163.1577.3.12

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