Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis.

Abstract excerpt

The aim of the present study was to evaluate the association of single nucleotide polymorphisms (SNPs) in toll-like receptor 4 (TLR4) with chronic obstructive pulmonary disease (COPD) in Han Chinese patients with chronic periodontitis (CP). Six candidate SNPs of TLR4-rs10759930, rs10983755, rs11536879, rs1927907, rs11536889 and -and 18 haplotype-tagging SNPs (tagSNPs) were genotyped in 339 patients with...