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Article

Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population.

Journal of periodontal research - 1 Dec 2007

Fukusaki T, Ohara N, Hara Y, Yoshimura A, Yoshiura K

Abstract excerpt

BACKGROUND AND OBJECTIVE: Chronic periodontitis is an inflammatory disease caused by bacteria in subgingival pockets. Because Toll-like receptor 2 and Toll-like receptor 4 have been shown to play an important role in the recognition of periodontal pathogens, we investigated the relevance of genetic variations in TLR2 and TLR4 to susceptibility to periodontitis. MATERIAL AND METHODS: A total of 97 patients with...

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Source

Identifiers

PMID: 17956467
DOI: 10.1111/j.1600-0765.2007.00979.x

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population.PMID 17956467Read ↗

TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.Semantic proximity Read ↗

Toll-like receptors 2 and 4 gene polymorphisms in a Chinese population with periodontitis.Semantic proximity Read ↗

Association between TLR4 polymorphism and periodontitis susceptibility: a meta-analysis.Semantic proximity Read ↗

Polymorphism of genes encoding toll-like receptors and inflammatory cytokines in periodontal disease in the Japanese population.Semantic proximity Read ↗

Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis.Semantic proximity Read ↗

TLR4 as a risk factor for periodontal disease: a reappraisal.Semantic proximity Read ↗

Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene.Semantic proximity Read ↗

Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis.Semantic proximity Read ↗

Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis.Semantic proximity Read ↗

Lack of association between chronic periodontitis and the Toll-like receptor 4 gene polymorphisms in a Czech population.Semantic proximity Read ↗

Influence of cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms in periodontitis.Semantic proximity Read ↗

Genetic risk factors for periodontitis in a Japanese population.Semantic proximity Read ↗

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