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Article

Mutant p53 promotes epithelial-mesenchymal plasticity and enhances metastasis in mammary carcinomas of WAP-T mice.

International journal of cancer - 15 Mar 2015

Lenfert Eva, Maenz Claudia, Heinlein Christina, Jannasch Katharina, Schumacher Udo, Pantel Klaus, Tolstonog Genrich V, Deppert Wolfgang, Wegwitz Florian

Abstract excerpt

To study the postulated mutant p53 (mutp53) "gain of function" effects in mammary tumor development, progression and metastasis, we crossed SV40 transgenic WAP-T mice with mutant p53 transgenic WAP-mutp53 mice. Compared to tumors in monotransgenic WAP-T mice, tumors in bitransgenic WAP-T x WAP-mutp53 mice showed higher tumor grading, enhanced vascularization, and significantly increased metastasis. Bitransgenic...

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Source

Identifiers

PMID: 25195563
DOI: 10.1002/ijc.29186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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