Development of novel mouse models to study the p53 tumour suppressor

Abstract excerpt

TP53 is the most commonly mutated gene in all human cancers [Vogelstein, 1990] and co- ordinates many of the cellular responses to DNA damage. It is vitally important therefore that we gain a better understanding of the function and regulation of p53. Since a major consequence of p53 mutation is cancer, a disease of complex multicellular organisms, the best system to study the real complexities of p53 function and...

Topics

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• Disease Models, Animal
• Forecasting
• Genes, p53
• Genetic Predisposition to Disease
• Mice
• Mice, Transgenic
• Mutation
• Neoplasms, Experimental

Identifiers and source

Literature Corpus work

c6e2daa5-d35c-55a3-b773-686f9d42cb6d

DOI

10.17638/03062816