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Article

The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation?

The Journal of cell biology - 19 Aug 2002

Mehta Shwetal, Yang Xian Mei, Chan Clarence S, Dobson Melanie J, Jayaram Makkuni, Velmurugan Soundarapandian

Abstract excerpt

The yeast 2 micron plasmid achieves high fidelity segregation by coupling its partitioning pathway to that of the chromosomes. Mutations affecting distinct steps of chromosome segregation cause the plasmid to missegregate in tandem with the chromosomes. In the absence of the plasmid stability system, consisting of the Rep1 and Rep2 proteins and the STB DNA, plasmid and chromosome segregations are uncoupled. The...

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Identifiers

PMID: 12177044
DOI: 10.1083/jcb.200204136
PMCID: PMC2174020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation?PMID 12177044Read ↗

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