Article
The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation?
The Journal of cell biology - 19 Aug 2002
Mehta Shwetal, Yang Xian Mei, Chan Clarence S, Dobson Melanie J, Jayaram Makkuni, Velmurugan Soundarapandian
Abstract excerpt
The yeast 2 micron plasmid achieves high fidelity segregation by coupling its partitioning pathway to that of the chromosomes. Mutations affecting distinct steps of chromosome segregation cause the plasmid to missegregate in tandem with the chromosomes. In the absence of the plasmid stability system, consisting of the Rep1 and Rep2 proteins and the STB DNA, plasmid and chromosome segregations are uncoupled. The...
Topics
- Bacterial Proteins
- Cell Cycle
- Cell Cycle Proteins
- Chromatids
- Chromosomal Proteins, Non-Histone
- Chromosome Segregation
- Chromosomes
- DNA, Fungal
- DNA-Binding Proteins
- Fungal Proteins
- G1 Phase
- Kinetochores
- Mutation