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Article

Cellular quality control screening to identify amino acid pairs for substituting the disulfide bonds in immunoglobulin fold domains.

The Journal of biological chemistry - 1 Jul 2005

Hagihara Yoshihisa, Matsuda Tomoki, Yumoto Noboru

Abstract excerpt

We are interested in determining which amino acid pairs can be substituted for the disulfide (S-S) bonds in proteins without disrupting their native structures under physiological conditions. In this study, we focused on the intradomain S-S bonds in Ig fold domains and aimed to determine a simple rule for replacement of their S-S bonds. The cysteines of four different Ig fold domains were mutated randomly, and...

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Identifiers

PMID: 15870065
DOI: 10.1074/jbc.M503963200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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