Article
KIT overexpression and amplification in gastrointestinal stromal tumors (GISTs).
Biochimica et biophysica acta - 30 Jun 2005
Tabone Séverine, Théou Nathalie, Wozniak Agnieszka, Saffroy Raphael, Deville Laure, Julié Catherine, Callard Patrice, Lavergne-Slove Anne, Debiec-Rychter Maria, Lemoine Antoinette, Emile Jean-François
Abstract excerpt
The tyrosine kinase receptor KIT plays a major role in gastrointestinal stromal tumors (GISTs) oncogenesis. Indeed, 95% of GISTs express KIT protein, and about 70% exhibit activating mutations of the KIT gene. However, little is known about KIT overexpression mechanisms in these tumors, and the correlation with KIT mutations. GISTs with mutations within exon 11 (n=12) or 9 (n=1) of KIT were compared with GISTs...
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