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Article

A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.

Nature genetics - 1 Oct 2005

Tsuge Masataka, Hamamoto Ryuji, Silva Fabio Pittella, Ohnishi Yozo, Chayama Kazuaki, Kamatani Naoyuki, Furukawa Yoichi, Nakamura Yusuke

Abstract excerpt

Histone modification is a crucial step in transcriptional regulation, and deregulation of the modification process is important in human carcinogenesis. We previously reported that upregulation of SMYD3, a histone methyltransferase, promoted cell growth in human colorectal and hepatocellular carcinomas. Here we report significant associations between homozygosity with respect to an allele with three tandem...

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Share to 5' Flanking Region
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Neoplasms

Share to Promoter Regions, Genetic

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Share to Tandem Repeat Sequences

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 16155568
DOI: 10.1038/ng1638

Genes

SMYD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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