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Article

Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes.

Kidney international - 1 Feb 2009

Ijaz Adeel, Tejada Thor, Catanuto Paola, Xia Xiaomei, Elliot Sharon J, Lenz Oliver, Jauregui Alexandra, Saenz Maria O, Molano Ruth D, Pileggi Antonello, Ricordi Camillo, Fornoni Alessia

Abstract excerpt

C-jun N-terminal kinase (JNK) regulates both the development of insulin resistance and inflammation. Podocytes of the widely used db/db mouse model of diabetic nephropathy lose their ability to respond to insulin as albuminuria develops, in comparison to control db/+ mice. Here we tested whether JNK inhibition or its gene deletion would prevent albuminuria in experimental diabetes. Phosphorylated/total JNK was...

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Identifiers

PMID: 18971923
DOI: 10.1038/ki.2008.559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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