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Article

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.

The Journal of cell biology - 9 May 2005

Komatsu Masaaki, Waguri Satoshi, Ueno Takashi, Iwata Junichi, Murata Shigeo, Tanida Isei, Ezaki Junji, Mizushima Noboru, Ohsumi Yoshinori, Uchiyama Yasuo, Kominami Eiki, Tanaka Keiji, Chiba Tomoki

Abstract excerpt

Autophagy is a membrane-trafficking mechanism that delivers cytoplasmic constituents into the lysosome/vacuole for bulk protein degradation. This mechanism is involved in the preservation of nutrients under starvation condition as well as the normal turnover of cytoplasmic component. Aberrant autophagy has been reported in several neurodegenerative disorders, hepatitis, and myopathies. Here, we generated...

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Identifiers

PMID: 15866887
DOI: 10.1083/jcb.200412022
PMCID: PMC2171928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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