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Liver autophagy: physiology and pathology

1 Jun 2012

Abstract excerpt

Autophagy has long been thought of as a bulk degradation system in which cytoplasmic components are sequestered by double-membrane structures called autophagosomes, and the contents are then degraded after autophagosomes fuse with lysosomes. Genetic experiments in yeast identified a set of Autophagy-related (ATG) genes that are essential for autophagy. We have since elucidated many of the molecular underpinnings...

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PMID: 22661765
DOI: 10.1093/jb/mvs059

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