Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis.

Abstract excerpt

Autophagy, the lysosomal degradation and recycling of self material, has been implicated in a number of developmental and pathological conditions including aging, cancer, neurodegeneration, and insect metamorphosis. Surprisingly, Atg7 mutant flies are able to complete metamorphosis with only a slight delay, despite strongly reduced autophagy levels. Similarly, developmental elimination of the larval midgut...

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