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Article

Atg7 in development and disease: panacea or Pandora’s Box?

24 Sept 2015

Abstract excerpt

Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3...

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PMID: 26404030
DOI: 10.1007/s13238-015-0195-8

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