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Article

Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.

The Journal of biological chemistry - 24 Mar 2006

Asante-Appiah Ernest, Patel Sangita, Desponts Caroline, Taylor Jillian M, Lau Cheuk, Dufresne Claude, Therien Michel, Friesen Rick, Becker Joseph W, Leblanc Yves, Kennedy Brian P, Scapin Giovanna

Abstract excerpt

PTP-1B represents an attractive target for the treatment of type 2 diabetes and obesity. Given the role that protein phosphatases play in the regulation of many biologically relevant processes, inhibitors against PTP-1B must be not only potent, but also selective. It has been extremely difficult...

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Identifiers

PMID: 16407290
DOI: 10.1074/jbc.M511827200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16407290-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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