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Calcium-sensing receptor gene polymorphism Arg990Gly and its possible effect on response to cinacalcet HCl.

Pharmacogenetics and genomics - 1 Jan 2005

Rothe Hansjörg M, Shapiro Warren B, Sun Wei Y, Chou Shyan-Yih

Abstract excerpt

Cinacalcet, a novel calcimimetic compound, is effective in reducing parathyroid hormone (PTH) levels in approximately 70% of patients with secondary hyperparathyroidism. However, interindividual variations in the dose required to achieve the treatment goal have been noted in clinical studies. Our investigation examined the genetic polymorphisms of the calcium-sensing receptor (CaSR) gene as one possible cause of...

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PMID: 15864123
DOI: 10.1097/01213011-200501000-00005

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcium-sensing receptor gene polymorphism Arg990Gly and its possible effect on response to cinacalcet HCl.PMID 15864123Read ↗

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