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Article

MEN1-related hyperparathyroidism: response to cinacalcet and its relationship with the calcium-sensing receptor gene variant Arg990Gly.

European journal of endocrinology - 1 Aug 2012

Filopanti Marcello, Verga Uberta, Ermetici Federica, Olgiati Luca, Eller-Vainicher Cristina, Corbetta Sabrina, Persani Luca, Beck-Peccoz Paolo, Spada Anna

Abstract excerpt

OBJECTIVE: Primary hyperparathyroidism (PHPT) is a challenging problem in type 1 multiple endocrine neoplasia (MEN1) due to the high postsurgery recurrence rate. The aim was to evaluate the efficacy of cinacalcet in MEN1 patients in comparison with patients with sporadic PHPT (sPHPT) and the effect of Arg990Gly calcium-sensing receptor (CASR) polymorphism on the response to treatment. DESIGN: This is a...

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Source

Identifiers

PMID: 22577108
DOI: 10.1530/EJE-12-0117

Genes

MEN1
CASR
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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