Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice.

doi:10.1007/BF02454137

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Article

Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice.

Experimental brain research - 1 Jan 1997

Verina T, Norton J A, Sorbel J J, Triarhou L C, Laferty D, Richter J A, Simon J R, Ghetti B

Abstract excerpt

The phenotypic effect of the weaver mutation in the ventral midbrain of homozygous mutants is associated with the progressive loss of dopaminergic neurons. To discover whether the number of mesencephalic dopaminergic cells is altered in weaver heterozygotes (wv/+), we studied mice between 20 and...

Topics

Alleles
Animals
Atrophy
Cell Count
Dopamine
Female
GTP-Binding Proteins
Heterozygote
Male
Mesencephalon
Mice
Mice, Neurologic Mutants
Neurons
Point Mutation

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