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Article

Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice.

Experimental brain research - 1 Jan 1997

Verina T, Norton J A, Sorbel J J, Triarhou L C, Laferty D, Richter J A, Simon J R, Ghetti B

Abstract excerpt

The phenotypic effect of the weaver mutation in the ventral midbrain of homozygous mutants is associated with the progressive loss of dopaminergic neurons. To discover whether the number of mesencephalic dopaminergic cells is altered in weaver heterozygotes (wv/+), we studied mice between 20 and 365 days of age. We counted tyrosine hydroxylase (TH)-immunopositive cells in the substantia nigra (SN), retrorubral...

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PMID: 9028770
DOI: 10.1007/BF02454137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice.PMID 9028770Read ↗

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Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse.Semantic proximity Read ↗

Alterations in serotonin receptors in the neostriatum of weaver mutant mice.Semantic proximity Read ↗

Phenotypic effects of the weaver gene are evident in the embryonic cerebellum but not in the ventral midbrain.Semantic proximity Read ↗

In vitro evidence that the reduction in mesencephalic dopaminergic neurons in the weaver heterozygote is not due to a failure in target cell interaction.Semantic proximity Read ↗

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