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Article

Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.

Regulatory toxicology and pharmacology : RTP - 1 Aug 2016

Otsuki Noriyuki, Homma Takujiro, Fujiwara Hiroki, Kaneko Kenya, Hozumi Yasukazu, Shichiri Mototada, Takashima Mizuki, Ito Junitsu, Konno Tasuku, Kurahashi Toshihiro, Yoshida Yasukazu, Goto Kaoru, Fujii Satoshi, Fujii Junichi

Abstract excerpt

Trichloroethylene (TCE) has been implicated as a causative agent for Parkinson's disease (PD). The administration of TCE to rodents induces neurotoxicity associated with dopaminergic neuron death, and evidence suggests that oxidative stress as a major player in the progression of PD. Here we report on TCE-induced behavioral abnormality in mice that are deficient in superoxide dismutase 1 (SOD1). Wild-type (WT)...

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Identifiers

PMID: 27166294
DOI: 10.1016/j.yrtph.2016.05.007

Genes

SOD1

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