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Article

Derivation of osteoclasts from hematopoietic colony-forming cells in culture.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 1992

Kerby J A, Hattersley G, Collins D A, Chambers T J

Abstract excerpt

The osteoclast is known to be derived from the hematopoietic stem cell, but its lineage remains controversial. There is evidence that osteoclastic differentiation is induced through a contact-dependent interaction between bone marrow stromal cells and hematopoietic precursors. To analyze osteocla...

Topics

Animals
Cells, Cultured
Culture Media
Granulocyte-Macrophage Colony-Stimulating Factor
Hematopoietic Stem Cells
Macrophage Colony-Stimulating Factor
Macrophages, Alveolar
Mice
Mice, Inbred Strains
Osteoclasts
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spleen

Stem Cells

Source

Identifiers

PMID: 1585838
DOI: 10.1002/jbmr.5650070316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1585838-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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