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Article

Derivation of osteoclasts from hematopoietic colony-forming cells in culture.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 1992

Kerby J A, Hattersley G, Collins D A, Chambers T J

Abstract excerpt

The osteoclast is known to be derived from the hematopoietic stem cell, but its lineage remains controversial. There is evidence that osteoclastic differentiation is induced through a contact-dependent interaction between bone marrow stromal cells and hematopoietic precursors. To analyze osteoclastic lineage, colonies were generated in semisolid medium from mouse spleen cells in the presence of Wehi-conditioned...

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Identifiers

PMID: 1585838
DOI: 10.1002/jbmr.5650070316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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