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Article

Identification of osteoclast precursors in multilineage hemopoietic colonies.

Endocrinology - 1 Jan 1991

Hattersley G, Kerby J A, Chambers T J

Abstract excerpt

The osteoclast is known to be derived from the hemopoietic stem cell, but its lineage and the mechanisms by which its differentiation is regulated are largely unknown. There is evidence that osteoclastic differentiation is induced through a contact-dependent interaction between bone marrow stromal cells and hemopoietic precursors. To analyze osteoclastic lineage, colonies were generated in semi-solid medium from...

Topics

Animals
Bone Resorption
Cells, Cultured
Clone Cells
Culture Media
Hematopoietic Stem Cells
Leukocytes
Mice
Mice, Inbred Strains
Osteoclasts
Phenotype
Spleen

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Identifiers

PMID: 1986920
DOI: 10.1210/endo-128-1-259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1986920-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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