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Myeloid blasts are the mouse bone marrow cells prone to differentiate into osteoclasts

20 Mar 2009

Abstract excerpt

Cells of the myeloid lineage at various stages of maturity can differentiate into multinucleated osteoclasts. Yet, it is unclear which developmental stages of this lineage are more prone to become osteoclasts than others. We investigated the osteoclastogenic potential of three successive stages of myeloid development isolated from mouse bone marrow. Early blasts (CD31hi/Ly-6C-), myeloid blasts (CD31+/Ly-6C+), and...

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PMID: 19304896
DOI: 10.1189/jlb.0708402

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