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Article

Protein kinase A mediates regulation of gap junctions containing connexin35 through a complex pathway.

Brain research. Molecular brain research - 27 Apr 2005

Ouyang Xiaosen, Winbow Virginia M, Patel Leena S, Burr Gary S, Mitchell Cheryl K, O'Brien John

Abstract excerpt

Connexin 35 (Cx35) is a major component of electrical synapses in the central nervous system. Many gap junctions containing Cx35 are regulated by dopamine receptor pathways that involve protein kinase A (PKA). To study the mechanism of PKA regulation, we analyzed direct phosphorylation of Cx35 by PKA in vitro and studied the regulation of neurobiotin tracer coupling in HeLa cells expressing Cx35 or Cx35 mutants...

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Identifiers

PMID: 15857663
DOI: 10.1016/j.molbrainres.2004.10.045
PMCID: PMC2212611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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