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Article

Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.

Drug metabolism and pharmacokinetics - 1 Apr 2005

Taguchi Masato, Hongou Kazuhisa, Yagi Shinichi, Miyawaki Toshio, Takizawa Miwako, Aiba Tetsuya, Hashimoto Yukiya

Abstract excerpt

Two research groups have reported the effect of genetic polymorphisms of CYP2C9 and CYP2C19 on the pharmacokinetic parameters of phenytoin in Japanese epileptic patients. We measured the plasma phenytoin concentrations at steady-state in 20 routinely treated Japanese patients, and evaluated the usefulness of genotyping the CYP2C subfamily in predicting plasma concentrations and determining the dosage regimens of...

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Identifiers

PMID: 15855721
DOI: 10.2133/dmpk.20.107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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