Article
Benznidazole therapy in Trypanosoma cruzi-infected mice blocks thymic involution and apoptosis of CD4+CD8+ double-positive thymocytes.
Antimicrobial agents and chemotherapy - 1 May 2005
Olivieri B P, Farias-De-Oliveira D A, Araujo-Jorge T C, Cotta-de-Almeida V
Abstract excerpt
Several alterations involving peripheral lymphoid organs have been extensively described after experimental Trypanosoma cruzi infection. Thymic involution occurs as well in infected mice, with both structural and functional alterations in the organ. Despite these abnormalities, specific immune response proceeds to control parasitemia and the participation of T lymphocytes is essential. However, there are...
Topics
- Animals
- Apoptosis
- Atrophy
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Death
- Chagas Disease
- Flow Cytometry
- Fluorescent Antibody Technique
- Male
- Mice
- Microscopy, Confocal
- Nitroimidazoles