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Article

Benznidazole therapy in Trypanosoma cruzi-infected mice blocks thymic involution and apoptosis of CD4+CD8+ double-positive thymocytes.

Antimicrobial agents and chemotherapy - 1 May 2005

Olivieri B P, Farias-De-Oliveira D A, Araujo-Jorge T C, Cotta-de-Almeida V

Abstract excerpt

Several alterations involving peripheral lymphoid organs have been extensively described after experimental Trypanosoma cruzi infection. Thymic involution occurs as well in infected mice, with both structural and functional alterations in the organ. Despite these abnormalities, specific immune response proceeds to control parasitemia and the participation of T lymphocytes is essential. However, there are...

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Identifiers

PMID: 15855522
DOI: 10.1128/AAC.49.5.1981-1987.2005
PMCID: PMC1087625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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