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Article

Differential susceptibility to acute Trypanosoma cruzi infection in BALB/c and C57BL/6 mice is not associated with a distinct parasite load but cytokine abnormalities.

Clinical and experimental immunology - 1 Jun 2002

Roggero E, Perez A, Tamae-Kakazu M, Piazzon I, Nepomnaschy I, Wietzerbin J, Serra E, Revelli S, Bottasso O

Abstract excerpt

Inoculation of Trypanosoma cruzi, Tulahuén strain, into C57BL/6 and BALB/c mice led to an acute infection characterized by marked parasitaemia, myocardial inflammation and thymocyte depletion. While C57BL/6 mice showed a progressive and lethal disease, BALB/c mice partly recovered. To characterize these murine models more effectively, we studied the parasite burden, serum levels of major infection outcome-related...

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Identifiers

PMID: 12067296
DOI: 10.1046/j.1365-2249.2002.01874.x
PMCID: PMC1906265

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TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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