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Article

Differential tissue distribution of discrete typing units after drug combination therapy in experimental Trypanosoma cruzi mixed infection.

Parasitology - 1 Nov 2021

Strauss Mariana, Lo Presti M Silvina, Ramírez Juan C, Bazán P Carolina, Velázquez López Daniela A, Báez Alejandra L, Paglini Patricia A, Schijman Alejandro G, Rivarola Héctor W

Abstract excerpt

The aim of the present work was to evaluate the distribution of the different clones of the parasite prevailing after treatment with benznidazole (BZ) and clomipramine (CLO), in mice infected with Trypanosoma cruzi, Casibla isolate which consists of a mixture of two discrete typing units (DTUs). Albino Swiss mice were infected and treated with high and low concentrations of BZ (100 or 6.25 mg/kg), CLO (5 or 1.25...

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Identifiers

PMID: 35060468
DOI: 10.1017/S0031182021001281
PMCID: PMC11010057

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