Article
The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome.
Clinical endocrinology - 1 May 2005
Hahn Susanne, Fingerhut Anja, Khomtsiv Ulyana, Khomtsiv Liliya, Tan Susanne, Quadbeck Beate, Herrmann Burkhard L, Knebel Birgit, Müller-Wieland Dirk, Mann Klaus, Janssen Onno E
Abstract excerpt
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and chronic anovulation. The genetic background of the insulin resistance frequently associated with PCOS is unclear. OBJECTIVES: To examine the influe nce of the Pro12Ala polymorphism of the peroxisome proliferator activated receptor gamma (PPARgamma), which is thought to play a role in the regulation of insulin sensitivity, on...
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