Article
The Pro12Ala polymorphism of the PPAR-gamma gene is not associated with the polycystic ovary syndrome.
Hormones (Athens, Greece) - 1 Jan 2000
Xita Nectaria, Lazaros Leandros, Georgiou Ioannis, Tsatsoulis Agathocles
Abstract excerpt
OBJECTIVE: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated- receptor-gamma (PPAR-gamma) has been implicated in insulin resistance and adiposity. The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism of the PPAR-gamma gene in the pathogenesis of PCOS. DESIGN: We studied 180 women with PCOS and 140...
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