Article
Maternal smoking during pregnancy and child emotional problems: the relevance of maternal and child 5-HTTLPR genotype.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2012
Cents Rolieke A M, Tiemeier Henning, Velders Fleur P, Jaddoe Vincent W V, Hofman Albert, Verhulst Frank C, Lambregtse-van den Berg Mijke P, Hudziak James J
Abstract excerpt
Serotonin is involved in the development of neural circuits modulating emotional behavior. The short allele (s) of a polymorphism (5-HTTLPR) of the serotonin transporter gene is a risk factor for psychopathology in the presence of environmental stressors. Maternal smoking is associated with growth restriction of the human fetal brain and adverse effects of nicotine on the developing serotonin system have been...
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