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Article

Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex

26 Apr 2005

Abstract excerpt

Children with tuberous sclerosis complex (TSC) harbor developmental brain abnormalities (cortical tubers) and low-grade tumors (subependymal giant cell astrocytomas [SEGAs]). Using gene expression profiling to identify neuroglial differentiation markers in Tsc1 conditional knockout mice, the authors demonstrate that giant cells of SEGAs aberrantly express similar neuroglial differentiation markers as do cortical...

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PMID: 15851742
DOI: 10.1212/01.wnl.0000158653.81008.49

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