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Article

Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle.

Genes & development - 1 Aug 2011

Zhou Jing, Shrikhande Gayatri, Xu Jing, McKay Renée M, Burns Dennis K, Johnson Jane E, Parada Luis F

Abstract excerpt

Subependymal nodules (SENs) and subependymal giant cell astrocytomas (SEGAs) are common brain lesions found in patients with tuberous sclerosis complex (TSC). These brain lesions present a mixed glioneuronal phenotype and have been hypothesized to originate from neural stem cells. However, this hypothesis has not been tested empirically. Here, we report that loss of Tsc1 in mouse subventricular zone (SVZ) neural...

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Identifiers

PMID: 21828270
DOI: 10.1101/gad.16750211
PMCID: PMC3182017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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