Article

Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

2021-06-16

Abstract excerpt

<title>Abstract</title> <p>Tuberous sclerosis complex (TSC) is a monogenic disorder caused by mutations in either the <italic>TSC1</italic> or <italic>TSC2</italic> gene, two key regulators of the mechanistic target of the rapamycin complex pathway. Phenotypically, this leads to growth and formation of hamartomas in several organs, including the brain. Subependymal giant cell astrocytomas (SEGAs) are low-grade br...

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Literature Corpus work: b43c5582-16ac-5260-986f-c7ab2b408976
DOI: 10.21203/rs.3.rs-586356/v1

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