Article
Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation.
Brain pathology (Zurich, Switzerland) - 1 Jan 2013
Prabowo Avanita S, Anink Jasper J, Lammens Martin, Nellist Mark, van den Ouweland Ans M W, Adle-Biassette Homa, Sarnat Harvey B, Flores-Sarnat Laura, Crino Peter B, Aronica Eleonora
Abstract excerpt
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the TSC1 or TSC2 genes and characterized by developmental brain abnormalities. We defined the spectrum of brain abnormalities in fetal TSC brain ranging from 23 to 38 gestational weeks. We hypothesized (i) prenatal activation of the target-of-rapamycin complex 1 (TORC1) signaling pathway; and (ii) activation of...
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