No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.

doi:10.1016/j.bbrc.2005.03.203

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Article

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.

Biochemical and biophysical research communications - 3 Jun 2005

Payne Felicity, Smyth Deborah J, Pask Rebecca, Cooper Jason D, Masters Jennifer, Wang William Y S, Godfrey Lisa M, Bowden Georgina, Szeszko Jeffrey, Smink Luc J, Lam Alex C, Burren Oliver, Walker Neil M, Nutland Sarah, Rance Helen, Undlien Dag E, Rønningen Kjersti S, Guja Cristian, Ionescu-Tîrgovişte Constantin, Todd John A, Twells Rebecca C J

Abstract excerpt

Susceptibility to the autoimmune disease type 1 diabetes has been linked to human chromosome 6q27 and, moreover, recently associated with one of the genes in the region, TATA box-binding protein (TBP). Using a much larger sample of T1D families than those studied by others, and by extensive re-sequencing of nine other genes in the proximity, in which we identified 279 polymorphisms, 83 of which were genotyped in...

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Identifiers

PMID: 15850778
DOI: 10.1016/j.bbrc.2005.03.203

Genes

TBP
CCR6
DLL1
PDCD2
PHF10
PSMB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.PMID 15850778Read ↗

Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.Semantic proximity Read ↗

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.Semantic proximity Read ↗

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.Semantic proximity Read ↗

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.Semantic proximity Read ↗

Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.Semantic proximity Read ↗

No evidence of association between genetic variants of the PDCD1 ligands and SLE.Semantic proximity Read ↗

Lack of association between IL27 gene variants and type 1 diabetes susceptibility.Semantic proximity Read ↗

Physical and genetic mapping of IDDM8 on chromosome 6q27.Semantic proximity Read ↗

No linkage or association of telomeric and centromeric T-cell receptor beta-chain markers with susceptibility to type 1 insulin-dependent diabetes in HLA-DR4 multiplex families.Semantic proximity Read ↗

No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex.Semantic proximity Read ↗

Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits.Semantic proximity Read ↗

A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes.Semantic proximity Read ↗

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