Article
No linkage or association of telomeric and centromeric T-cell receptor beta-chain markers with susceptibility to type 1 insulin-dependent diabetes in HLA-DR4 multiplex families.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Oct 1996
McDermott M F, Schmidt-Wolf G, Sinha A A, Koo M, Porter M A, Briant L, Cambon-Thomsen A, Maclaren N K, Fiske D, Bertera S, Trucco M, Amos C I, McDevitt H O, Kastner D L
Abstract excerpt
The T-cell receptor beta locus (TCRB) on chromosome 7q35 was studied as a candidate region for genetic susceptibility to type 1 insulin-dependent diabetes (IDDM). A highly polymorphic microsatellite marker mapping to the TCRBV6.7 gene and a TCRB C-region RFLP were used to genotype the members of a total of 21 multiplex IDDM families from two different geographical areas. There was no evidence to support linkage...
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