Article
Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
BMC genetics - 17 May 2007
Nejentsev Sergey, Smink Luc J, Smyth Deborah, Bailey Rebecca, Lowe Christopher E, Payne Felicity, Masters Jennifer, Godfrey Lisa, Lam Alex, Burren Oliver, Stevens Helen, Nutland Sarah, Walker Neil M, Smith Anne, Twells Rebecca, Barratt Bryan J, Wright Charmain, French Lisa, Chen Yuan, Deloukas Panagiotis, Rogers Jane, Dunham Ian, Todd John A
Abstract excerpt
BACKGROUND: In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined analysis of the main linkage scans. Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D....
Topics
- Case-Control Studies
- Chromosomes, Human, Pair 10
- DNA Primers
- Diabetes Mellitus, Type 1
- Female
- Gene Frequency
- Genetic Markers
- Genotype
- Humans