Article
Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation.
Cell death and differentiation - 1 Jun 2005
Hendriks J, Planelles L, de Jong-Odding J, Hardenberg G, Pals S T, Hahne M, Spaargaren M, Medema J P
Abstract excerpt
APRIL, a proliferation-inducing ligand, is a member of the tumor necrosis factor (TNF) family that is expressed by various types of tumors and influences their growth in vitro and in vivo. Two receptors, transmembrane activator and cyclophilin ligand interactor (TACI) and B-cell maturation antigen (BCMA), bind APRIL, but neither is essential for the tumor-promoting effects, suggesting that a third receptor...
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